08-01 Neurochemical endophenotypes of schizophrenia
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چکیده
منابع مشابه
08 Corcoran 01-01.qxd
January 2001 3 This review explores the neurobiology of stress and its possible role in the etiology of schizophrenia. Major life events may play a role in onset and relapse in schizophrenia. Other data suggest that early stress exposure increases schizophrenia risk, especially in individuals with latent vulnerability. Animal research has led to an elucidation of the mechanisms by which stress ...
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Recent advances in the development and applications of neurochemical brain imaging methods have improved the ability to study the neurochemistry of the living brain in normal processes as well as psychiatric disorders. In particular, positron emission tomography (PET) and single photon emission computed tomography (SPECT) have been used to determine neurochemical substrates of schizophrenia and...
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The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
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The power and appeal of the molecular biology mantra, ‘‘DNA to RNA to protein,’’ to explicate cell biology comes from its universal appearance and application in all species, from microorganisms to human beings. Based on this mantra, the genomes of viruses, bacteria, fruit flies, and now humans are being mapped and sequenced, so that all the genes and, ultimately, their corresponding biological...
متن کاملNeurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.
In an effort to reveal susceptibility genes, schizophrenia research has turned to the endophenotype strategy. Endophenotypes are characteristics that reflect the actions of genes predisposing an individual to a disorder, even in the absence of diagnosable pathology. Individual endophenotypes are presumably determined by fewer genes than the more complex phenotype of schizophrenia and would, the...
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ژورنال
عنوان ژورنال: Acta Neuropsychiatrica
سال: 2006
ISSN: 0924-2708,1601-5215
DOI: 10.1017/s0924270800032294